2020

 

Gomes AP, Ilter D, Low V, Endress JE, Fernández-García J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt S-M, Blenis J. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020 Aug 19. PMID: 32814897.

Featured in: Harjes, Ulrike. Metabolic ageing drives tumour progression. Nature Reviews Cancer. 2020 Aug 28. PMID: 32860014

Featured in: Serum Methylmalonic Acid Mediates Aging-Related Cancer Aggressiveness

Low V, Blenis J, Gomes AP. Targeting the premetastatic niche: epigenetic therapies in the spotlight. Signal Transduction and Targeted Therapy. 2020 May 11;5(1):68. PMID: 32390001; PMCID: PMC7211564.

Ilter D, Blenis J, Gomes AP. Histone H3 variants at the root of metastasis. Molecular & Cellular Oncology. 2020 Jan 10;7(2):1684128. PMID: 32158911; PMCID: PMC7051143.

 

2019

 

Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massagué J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. PMID: 31564638; PMCID: PMC6801101.

Featured in: Simeonova I, Almouzni G. Dynamic Histone H3 Incorporation Fuels Metastatic Progression. Trends in Molecular Medicine. 2019 Nov;25(11):933-935. PMID: 31624022.

 

2018

 

Rosenzweig A, Blenis J, Gomes AP. Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism? Frontiers in Cell and Developmental Biology 2018 Aug 15;6:90. PMID: 30159313; PMCID: PMC6103474.

He L, Gomes AP, Wang X, Yoon SO, Lee G, Nagiec MJ, Cho S, Chavez A, Islam T, Yu Y, Asara JM, Kim BY, Blenis J. mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Molecular Cell. 2018 Jun 7;70(5):949-960.e4. PMID: 29861159; PMCID: PMC6591025.

Schild T, Low V, Blenis J, Gomes AP. Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. Cancer Cell. 2018 Mar 12;33(3):347-354. PMID: 29533780; PMCID: PMC5889305.

Teodoro JS, Varela AT, Duarte FV, Gomes AP, Palmeira CM, Rolo AP. Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers. European Journal of Clinical Investigation. 2018 Jun;48(6):e12932. PMID: 29603199.

Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Molecular Metabolism. 2018 Jan;7:1-11. PMID: 29146412; PMCID: PMC5784330.

 

2017

 

Gomes AP, Schild T, Blenis J. Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. Developmental Cell. 2017 Jul 24;42(2):112-114. PMID: 28742999; PMCID: PMC5705022.

Duarte FV, Amorim JA, Varela AT, Teodoro JS, Gomes AP, Cunha RA, Palmeira CM, Rolo AP. Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver. Purinergic Signalling. 2017 Jun;13(2):179-190. PMID: 27848069; PMCID: PMC5432478.

 

2016

 

Teodoro JS, Gomes AP, Varela AT, Duarte FV, Rolo AP, Palmeira CM. Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats. Toxicology Mechanisms and Methods. 2016 Nov;26(9):650-657. PMID: 27790925.

Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancersPNAS. 2016 Feb 16;113(7):1778-83. PMID: 26831078; PMCID: PMC4763784.

 

2015

 

Gomes AP, Blenis J. A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Current Opinion in Biotechnology. 2015 Aug;34:110-7. PMID: 25562138; PMCID: PMC4490161.

Gomes AP, Sinclair DA. Measuring PGC-1α and its acetylation status in mouse primary myotubes. Methods in Molecular Biology. 2015;1241:49-57. PMID: 25308487.

Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM. The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. European Heart Journal. 2015 Jan 1;36(1):51-9. PMID: 24603306; PMCID: PMC4286317.

 

2014

 

Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 2014 Oct;13(5):787-96. PMID: 24931715; PMCID: PMC4172519.

Teodoro JS, Zouhar P, Flachs P, Bardova K, Janovska P, Gomes AP, Duarte FV, Varela AT, Rolo AP, Palmeira CM, Kopecký J. Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice. International Journal of Obesity. 2014 Aug;38(8):1027-34. PMID: 24310401.

Wu LE, Gomes AP, Sinclair DA. Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis. Cancer Cell. 2014 Jan 13;25(1):12-9. PMID: 24434207; PMCID: PMC3970212.

 

2013

 

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19; 155(7):1624-38. PMID: 24360282; PMCID: PMC4076149.

Featured in: Prolla TA, Denu JM. NAD+ deficiency in age-related mitochondrial dysfunction. Cell Metabolism. 2014 Feb 4;19(2):178-80. PMID: 24506863.

Featured in: Christian BE, Shadel GS. Aging: it's SIRTainly possible to restore mitochondrial dysfunction. Current Biology. 2014 Mar 3;24(5):R206-8. PMID: 24602889.

Teodoro JS, Duarte FV, Gomes AP, Varela AT, Peixoto FM, Rolo AP, Palmeira CM. Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. Mitochondrion. 2013 Nov;13(6):637-46. PMID: 24041461.

Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle. 2013 Jul 15;12(14):2233-40. PMID: 23892437; PMCID: PMC3755073.

Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013 Mar 8;339(6124):1216-9. PMID: 23471411; PMCID: PMC3799917.

Teodoro JS, Gomes AP, Varela AT, Duarte FV, Rolo AP, Palmeira CM. Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damageMolecular and Cellular Biochem. 2013;376(1-2):103-110. PMID: 23292031.

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Metformin improves healthspan and lifespan in mice. Nature Communications. 2013;4:2192. PMID: 23900241; PMCID: PMC3736576.

Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr;62(4):1084-93. PMID: 23172919; PMCID: PMC3609577.

 

2012

 

Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism. 2012 May 2;15(5):675-90. PMID: 22560220; PMCID: PMC3545644.

Featured in: Denu JM. Fortifying the link between SIRT1, resveratrol, and mitochondrial function. Cell Metabolism. 2012 May 2;15(5):566-7. PMID: 22560207; PMCID: PMC3491563.

Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochimica et Biophysica Acta. 2012 Feb;1822(2):185-95. PMID: 22027215; PMCID: PMC3366688.

 

Pre-2012

 

Rolo AP, Gomes AP, Palmeira CM. Regulation of mitochondrial biogenesis in metabolic syndrome. Current Drug Targets. 2011 Jun;12(6):872-8. PMID: 21269264.

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. SRT1720 improves survival and healthspan of obese mice. Scientific Reports. 2011;1:70. PMID: 22355589; PMCID: PMC3216557.

Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging. 2010 Dec;2(12):914-23. PMID: 21212461; PMCID: PMC3034180.

Varela AT, Simões AM, Teodoro JS, Duarte FV, Gomes AP, Palmeira CM, Rolo AP. Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3beta and mitochondrial permeability transition. Mitochondrion. 2010 Aug;10(5):456-63. PMID: 20433952.

Varela AT, Gomes AP, Simões AM, Teodoro JS, Duarte FV, Rolo AP, Palmeira CM. Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction. Toxicology and Applied Pharmacology. 2008 Dec 1;233(2):179-85. PMID:18786556.